Craig Niederberger, M.D.

Chief, Division of Andrology and Director, Urologic Basic Research

Associate Professor, Department of Urology

Associate Professor, Department of Obstetrics/Gynecology,

Associate Professor, Department of Genetics

 

University of Illinois at Chicago College of Medicine

840 South Wood Street, M/C 955

Chicago, Illinois, 60612-7316

(312) 996-2779, fax: (312) 996-1291

Birthplace: San Diego, California (August 9, 1960)

 

 

1 Academic Training

 

Undergraduate: B.S., 1982 Harvey Mudd College, Claremont, California (Graduation with Distinction, and Honors in the Humanities and Social Sciences,(Dual Majors in Chemistry and Theater)

Graduate: M.D., 1986 University of Pittsburgh, Pittsburgh, Pennsylvania (Honors in Urology, Psychiatry, Medical Problem Solving, Radiology, Emergency Medicine)

Residency:

   ‑Surgery: 1986‑1988, Michael Reese Hospital, Chicago, Illinois

   ‑Urology: 1988‑1991, Michael Reese Hospital and University of Illinois at Chicago,           Chicago, Illinois

Fellowship: Andrology, 1991‑1993 Baylor College of Medicine, Houston, Texas (Preceptors Dolores J. Lamb, Ph.D., and Larry I. Lipshultz, M.D.)

 

2 Grants

 

American Fertility Society / Serono Research Grant Recipient 1991‑1992

American Urological Association /American Foundation for Urological Disease Research Scholar  1991‑1993

 

NIH R01‑HD30155‑01 Co‑investigator: Correlates of Fertility in Spinal Cord Injured Men 1992‑1997

  

American Urological Association / American Foundation for Urological Disease / Searle New Investigator Research Award N194‑04 1994‑1996

 

Health Foundation of South Florida Co‑investigator: Predictors of psychosocial outcomes in South  Florida prostate cancer patients 1994‑1996

 

 

3 Medical Certification and Licensure

  

   National Board of Medical Examiners, Diplomate 1987

   State of Illinois 1988 (036‑076974)

   State of California 1990 (C 069693)

   ESWL (Michael Reese Hospital, Chicago, Illinois) 1991

   Board Certified, American Board of Urology, 1995

 

4 Professional Societies

 

Chicago Urological Society, Member

Chicago Medical Society, Member

Illinois State Medical Society, Member

Illinois State Urological Society, Member

American Medical Association, Member

American College of Surgeons, Fellow

American Urological Association, Member

American Fertility Society, Member

Society for the Study of Male Reproduction, Member

Society for Basic Urologic Research, Member

American Society of Andrology, Member

American Association for the Advancement of Science, Member

American Chemical Society, Member

Endocrine Society, Member

American Society for Cell Biology, Member        

 

5 Awards

 

In Situ Testis Expression of DAZ and DAZLA in Mouse and Man, Society for Male  Reproduction and Urology Prize Paper, 53rd Annual Meeting of the American Society for Reproductive Medicine, October, 1997

 

President Citation for the American Society of Andrology for exceptional contribution in the area of Science Communication, 23rd Annual Meeting of the American Society of Andrology, April, 1998

 

First place winner, Jackson Hole Urological meeting, January 1999

 

6 Publications (peer‑reviewed)

 

1. Saslawsky M, Niederberger C, Schacht M, Prinz L, Ross L: Ureterocutaneous fistula: a case report of treatment by subtrigonal injection of polytetrafluoroethylene (STING procedure):The Journal of Urology, 142: 1310‑1311, 1989

 

2. Schacht M, Niederberger C, Garnett J, Sensibar JA, Lee C, Grayhack JT: Pitu­itary‑prostate grafts: demonstration of a local effect of prolactin: Prostate, 20: 51‑581 1992

 

 

3. Niederberger C, Ross L, MacKenzie B, Schacht M, Cho Y: Vasovasostomy in rabbits using fibrin adhesive prepared from a single human source: The Journal of Urology, 149: 83‑1851 1993

 

4. Niederberger C, Lome L: Primary malignant melanoma of the urinary bladder: Urology, 41: 72‑741, 1993

 

5. Niederberger C, Ross L: Single tubule microsurgical epididymovasostomy: predictors of  success: The Journal of Urology, 149: 1364‑1367, 1993

 

6. Niederberger CS, Lamb DJ, Glinz M, Lipshultz LI, Scully NF: Tests of sperm function for  evaluation of the male: Penetrak and Tru‑Trax: Fertility and Sterility, 60: 319‑323, 1993

 

 7. Niederberger CS, Lipshultz LI, Lamb DJ: A neural network to analyze fertility data: Fertility and  Sterility, 60: 324‑330, 1993

 

8. Niederberger C, Shubhada S, Lamb DJ: Paracrine regulation of spermatogenesis: World Journal of Urology, 11: 120‑128, 1993

 

9. Lamb DJ, Niederberger C: Application of artificial intelligence systems in medicine: World Journal of Urology, 11: 129‑136, 1993

 

10. Lamb DJ, Niederberger C: Animal models that mimic human male reproductive defects: Urologic Clinics of North America, 21: 377‑387, 1994

 

11. Niederberger CS, Ross LS, Cho Y, Pursell S, Rizvi S, Glinz M, Maislos S, Kim S, Lipshultz, LI,  Lamb, DJ: Genetic regulation of spermatogenesis: Molecular Andrology, 6: 270‑2807, 1994

 

12. Qin Y, Lamb DJ, Golden RM, Niederberger C: A neural network predicts mortality and new metastases in patients with renal cell cancer: Proceedings of the First World Congress on Computational Medicine, Public Health and Biotechnology‑Building a Man in the  Machine, Part III, Series in Mathematical Biology and Medicine, Volume 5: 1325‑13341,1994

 

13. Niederberger CS, Ross LS, Lipshultz LI, Lamb DJ, Golden R: Artificial intelligence: the  new frontier of fertility data analysis: ARTA 7: 57‑68, 1995

 

14. Niederberger CS: Commentary on the use of neural networks in clinical urology: The  Journal of Urology, 153: 1362, 1995

 

15. Ross LS, Niederberger CS: Male infertility: diagnosis and treatment: Comprehensive  Therapy, 21: 276‑2821 1995

 

16. Spear KA, Niederberger CS: Male infertility: evaluation and treatment: Journal of Urological Nursing, 15: 1182‑1193, 1996

 

17. Meacham RB, Niederberger CS: Use of a moderated international Internet information  exchange in the study of male reproduction: Urology, 48: 3‑6, 1996

 

18. Niederberger CS, Michaels EK, Cho L, Hong Y, Brown B, Ross LS, Golden RM: A neural computational model of stone recurrence after ESWL: Proceedings of the International  Conference on Engineering Applications of Neural Networks: 423‑426, 1996

 

19. Niederberger CS: Computational tools for the modern andrologist: Journal of Andrology,  17: 462‑ 4661, 1996

 

20. Krongrad A, Granville LJ, Burke MA, Golden RM, Lai S, Cho L, Niederberger CS: Predictors of general quality of life in patients with benign prostatic hyperplasia or prostate cancer: The Journal of Urology, 157: 534‑538, 1997

 

21. Ilekis JV, Cariti JG, Niederberger CS, Scoccia B: Expression of a truncated epidermal growth factor receptor‑like protein (TEGFR) in ovarian cancer: Gynecologic Oncology, 65: 36‑411, 1997

 

22. Niederberger C, Agulnik AI, Cho Y, Lamb D, Bishop CE: In situ hybridization shows that Dazla expression in mouse testis is restricted to premeiotic stages IV‑VI of spermatogenesis: Mammalian genome, 8: 277‑278, 1997

 

23. Katz D, Niederberger C, Slaughter GR, Cooney AJ: Characterization of germ cell‑specific expression of the orphan nuclear receptor, Germ Cell Nuclear Factor: Endocrinology, 138: 4364‑43721, 1997

 

24. Ilekis JV, Connor JP, Prins GP, Ferrer K, Niederberger CS, Scoccia B: Expression of  Epidermal Growth Factor and Androgen Receptors in Ovarian Cancer: Gynecologic  Oncology, 66: 250‑2541, 1997

 

25. Michaels EK, Niederberger CS, Golden RM, Brown B, Cho L, Hong Y: Use of a Neural  Network to Predict Stone Growth after Shock Wave Lithotripsy: Urology, 51: 335‑338, 1998

 

26. Agoulnik IY, Cho Y, Niederberger C, Kieback DG, Cooney AJ:  Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF: FEBS Letters, 424: 73‑78, 1998

 

27. Bagli JD, Agarwal SK, Venkateswaran S, Shuckett B, Khoury A, Merguerian PA, McLorie GA, Liu K, Niederberger CS: Artificial Neural Networks in Pediatric Urology: Prediction of Sonographic Outcome following Pyeloplasty, The Journal of Urology, 160:980-983, 1998

 

28. Prins GS, Dolgina R, Studney P, Kaplan B, Ross LS, Niederberger CS: Quality of Cryopreserved  Testicular  Sperm in Patients with Obstructive and Nonobstructive Azoospermia,  The Journal of Urology, 161: 1504-1508, 1999

 

7 Book Chapters

 

1. Lamb DJ, Niederberger CS: New statistical techniques that predict medical outcomes, in  Advances in Urology, volume 9, eds. McGuire EJ, Bloom D, Catalona WJ, Lipshultz LI; Mosby, St. Louis, 1996, pp. 407‑426

 

2. Niederberger CS, Pursell S, Golden RM: A neural network to predict lifespan and new metastases in patients with renal cell cancer, in Handbook of Neural Computation, eds. Fiesler E, Beale R, Axelrod T, Blayo F, Cios KJ, Doerschuk PI, Jain S, Murphy CL, Niederberger C, Torkkola K, Wellekens CJ; IOP Publishing and Oxford University Press, Oxford, 1997, pp. G5.4:1‑6

 

3. Niederberger CS, Lamb DJ: Spermatogenesis in the adult, in Infertility in the Male, 3rd  edition, eds. Lipshultz LI and Howards SS; Mosby, St. Louis, 1997, pp. 106‑122

 

4. Niederberger CS, Meacham R: Reproductive Medicine on the Internet and the World Wide Web: Male Infertility, 1999, pp. 621-630

 

8  Books

 

Associate Editor, Handbook of Neural Computation, eds. Fiesler E, Beale R, Axelrod T, Blayo F, Cios KJ, Doerschuk PI, Jain S, Murphy CL, Niederberger C, Torkkola K, Wellekens CJ; IOP Publishing and Oxford University Press, Oxford, 1997

 

Editor, Handbook of Medical Computation, Oxford University Press, New York, New York, in compilation

 

9 Abstracts

 

1. Single tubule microsurgical epididymovasostomy: predictors of success: Illinois Urological Society Meeting, Bloomington, Illinois, September, 1989

 

2. Single tubule microsurgical epididymovasostomy: predictors of success: 63rd Annual Meeting of the North Central Section of the American Urological Association, Chicago, Illinois, September 1989

 

3. Primary malignant melanoma of the bladder: 63rd Annual Meeting of the North Central Section of the American Urological Association, Chicago, Illinois, September 1989

 

4. The technique of specific tubule microsurgical epididymovasostomy: 64th Annual Meeting of the North Central Section of the American Urological Association, Colorado Springs, Colorado, October 1990

 

5. Clinical experience with the Uni‑flate 1000 penile prosthesis: 64th Annual Meeting of the North Central Section of the American Urological Association, Colorado Springs, Colorado, October 1990

 

6. Fibrinogen glue vasovasostomy: Chicago Urological Society, March 1991

 

7. Fibrinogen glue vasovasostomy: a no suture technique for vasal anastomosis: 47th Annual Meeting of the American Fertility Society, Orlando, Florida, October 1991

 

 

8. Fibrinogen glue vasovasostomy: a no suture technique for vasal anastomosis: 65th Annual Meeting of the North Central Section of the American Urological Association, Scottsdale, Arizona, November 1991

 

9. A method for quantification of sperm directed antibodies using the immunobead assay: 65th Annual Meeting of the North Central Section of the American Urological Association, Scottsdale, Arizona, November 1991

 

10. Tests of sperm function for the evaluation of the male: Penetrak and Tru‑Trax: 87th Annual Meeting of the American Urological Association, Washington DC, May 1992

 

11. The neural network as an artificial intelligence tool in Urology: Plenary speaker, Society for Basic Urologic Research Fall Symposium, St. Louis, Missouri, October 1992

 

12. The association of antisperm antibodies and leukocytospermia in subfertile men: 48th Annual Meeting of the American Fertility Society, New Orleans, Louisiana, November, 1992

 

13. Analysis of Sertoli cell gene expression by in‑situ hybridization: an optimized model system: 48th Annual Meeting of the American Fertility Society, New Orleans, Louisiana, November 1992

 

14. An improved technique for in‑situ hybridization: stage‑and cell‑specific gene expression in the testis:12th North American Testis Workshop, Tampa, Florida, April 1993

 

15. The neural network predicts gamete micromanipulation success: 7th Annual Meeting Society for Basic Urologic Research, San Antonio, Texas 1993

 

16. Artificial intelligence in urology and the future of molecular probes in testis biopsy: lst Annual Meeting of the Society for the Study of Male Reproduction, San Antonio, Texas 1993

 

17. Stage‑and cell‑specific gene expression in the testis: 88th Annual Meeting of the American Urological Association, San Antonio, Texas, 1993

 

18. The artificial neural network: a novel and powerful method of fertility data analysis: 88th Annual Meeting of the American Urological Association, San Antonio, Texas 1993

 

19. The diagnosis and treatment of primary obstructive azoospermia: 67th Annual Meeting of the North Central Section of the American Urological Association, Milwaukee, Wisconsin, September 1993

 

20. A neural network to predict gamete micromanipulation success: 67th Annual Meeting of the North Central Section of the American Urological Association, Milwaukee, Wisconsin, September 1993

 

21. A neural network to analyze fertility data and predict gamete micromanipulation success: 49th Annual Meeting of the American Fertility Society, Montreal, Quebec, October 1993

 

22. A neural network predicts mortality and new metastases in patients with renal cell cancer: Society for Basic Urologic Research Fall Symposium, Houston, Texas, December, 1993

 

23. Testis biopsies from infertile males with high normal FSH are accurately predicted by a neural network: 19th Annual Meeting of the American Society of Andrology, Springfield, Illinois, March 1994

 

24. A neural network predicts mortality and new metastases in patients with renal cell cancer: First World Congress on Computational Medicine, Public Health and Biotechnol­ogy, Austin, Texas, April 1994

 

25. Stage and cell specific expression of growth related genes in the testis: Society for Basic Urologic Research Spring Symposium, San Francisco, California, May 1994

 

26. A neural network predicts testis biopsy results: 89th Annual Meeting of the American Urological Association, San Francisco, California, May 1994

 

27. The immediate early gene nur77 is expressed in a cell‑and stage‑specific manner during spermatogenesis: 89th Annual Meeting of the American Urological Association, San Francisco, California, May 1994

 

28. Neural networks in diagnosing male infertility: Assisted Reproduction in the 21st Century, Chicago, Illinois, May 1994

 

29. The genetic regulation of spermatogenesis: ARTA Conference, Innsbruck, Austria, July 1994

 

30. Artificial intelligence: the new frontier of fertility data analysis: ARTA Conference, Innsbruck, Austria, July 1994

 

31. New issues in the management of Infertility and Impotence: Current Topics in Urology: New Directions in the 1990s, Peoria, Illinois, September 1994

 

32. Prediction of mortality and new metastases in patients with renal cell carcinoma using an artificial intelligence program (neUROn): 68th Annual Meeting of the North Central Section of the American Urological Association, Boca Raton, Florida, October 1994

 

33. The genetic regulation of spermatogenesis: 68th Annual Meeting of the North Central Section of the American Urological Association, Boca Raton, Florida, October 1994

 

34. Analysis of a neural network that predicts testis biopsy results with high accuracy: 50th Annual Meeting of the American Fertility Society, San Antonio, Texas, November 1994

 

35. In‑situ expression of a‑inhibin in human azoospermic males with Sertoli‑cell only histology: 34th Annual Meeting of the American Society for Cell Biology, San Francisco, California, December 1994

 

36. Expression of the immediate early gene nur77 in‑situ in murine and infertile human testis: 34th Annual Meeting of the American Society for Cell Biology, San Francisco, California, December 1994

37. Novel markers of quality of life: a potential framework for targeting prostate therapies: VA HSR&D Service Meeting, Washington D.C., February 1995

 

38. Human Sertoli‑cell only males display a characteristic pattern of nur‑77 expression in testis interstitial cells: 90th Annual Meeting of the American Urological Association, Las Vegas, Nevada, May 1995

 

39. Varicocelectomy outcomes are predicted by a neural network: 90th Annual Meeting of the American Urological Association, Las Vegas, Nevada, May 1995

 

40. New frontiers in male infertility: Minnesota Urological Society Annual Spring Seminar, Rochester, Minnesota, May 1995

 

41. An Internet program allowing global access to computational resources in urological decision making:  First Joint Meeting of the European and American Societies of Basic Urological Research, Rotterdam, Netherlands, August 1995

 

42. Postmortem sperm recovery and preservation: technique and issues for posthumous reproduction: 69th Annual Meeting of the North Central Section of the American Urological Association, Minneapolis, Minnesota, September 1995

 

43. Use of autologous fibrin adhesive in human vasovasostomy: 69th Annual Meeting of the North Central Section of the American Urological. Association, Minneapolis, Minnesota, September 1995

 

44. A computer model that predicts ICSI and SUZI outcomes: 51st Annual Meeting of the American Society for Reproductive Medicine, Seattle, Washington, October 1995

 

45. Double fluorescent stain for accurate assessment of human‑hamster ICSI outcome: 21st Annual Meeting of the American Society of Andrology, Minneapolis, Minnesota, April 1996

 

46. Methods for global data allocation in infertility: Society for the Study of Male Reproduction, 91st Annual Meeting of the American Urological Association, Orlando, Florida, May 1996

 

47. Open testicular sperm retrieval pre and post mortem: Society for the Study of Male Reproduction, 91st Annual Meeting of the American Urological Association, Orlando, Florida, May 1996

 

48. Mathematical modeling of biological and clinical phenomena: neural networks: Society for Basic Urological Research, 91st Annual Meeting of the American Urological Association, Orlando, Florida, May 1996

 

49, Stone recurrence after lithotripsy is predicted by a neural network: 91st Annual Meeting of the American Urological Association, Orlando, Florida, May 1996

 

50. Models of general quality of life (QOL) in prostate disease: a pilot study using neural networks: 91st Annual Meeting of the American Urological Association, Orlando, Florida, May 1996

 

51. A neural computational model of stone recurrence after ESWL: International Conference on Engineering Applications of Neural Networks (EANN '96), London, England, June 1996

 

52. Testicular sperm extraction (TESE) is an effective adjunct to vasal and epididymal reconstruction for obstructive azoospermia: 70th Annual Meeting of the North Central Section of the American Urological Association, Tucson, Arizona, October 1996

 

53. Identification of four novel genes and one not previously localized to testis that are differentially expressed during spermatogenesis: 52nd Annual Meeting of the American Society for Reproductive Medicine, Boston, Massachusetts, November 1996

 

54. Cryopreservation of sperm collected by TESE provides adequate post‑thaw viability and successful IVF‑ICSI pregnancies: 22nd Annual Meeting of the American Society of Andrology, Baltimore, Maryland, February 1997

 

55. Like human Sertoli‑cell Only males, c‑kit mutant mice over‑express nur‑77 in testis interstitial cells: 92nd Annual Meeting of the American Urological Association, New Orleans, Louisiana, April 1997

 

56. Routine testicular sperm extraction (TESE) during microsurgical vasal and epididymal reconstruction is safe and effective: 92nd Annual Meeting of the American Urological Association, New Orleans, Louisiana, April 1997

 

57. In Situ Testis Expression of DAZ and DAZLA in Mouse and Man: 53rd Annual Meeting of the American Society for Reproductive Medicine, Cincinnati, Ohio, October 1997

 

58. Autologous Fibrin Adhesives in Human Vasovasostomy: 53rd Annual Meeting of the American Society for Reproductive Medicine, Cincinnati, Ohio, October 1997

 

59. Local Anesthethetics Impair Human Sperm Motility: 23rd  Annual Meeting of the American Society of Andrology, Long Beach, California, April 1998

 

60. A Novel Technique For Assessing Ischemia‑reperfusion  Injury Using Autoradiography And Computer Enhanced  Image Processing. 94th American Urological Association Meeting Dallas, TX, May 1999

 

61. Varicolele Surgery Improves Sperm–Egg Penetration as Demonstrated by Sperm Penetration Assay (SPA) 94th American Urological Association Meeting Dallas, TX, May 1999

 

62. Expression of a Putative Negative Regulator of Epidermal  Growth Factor Receptor is Reduced in Prostate Cancer. San Diego, CA Endocrine 81st Annual Meeting, June 1999

 

63. Erb-B Receptors Activation Increases the Mitogenic Response and Metastatic Potential in Androgen Independent LnCap Variants: 75th Annual Meeting of the Western Section American Urological Association, Monterey, California, September 1999

 

64. Androgen Insensitive Prostate Cancer Cell Lines Androgen Sensitive in the Presence of Growth Factors: 73th Annual Meeting of the North Central Section of the American Urological Association, Chicago, IL September 1999.

 

65. Vaso-Epididymal Non-Union Syndorome (Venus): Results of Microsurgical Reconstructive and Testicular Biopsy: North Central Section 73rd Annual Meeting, Chicago, IL, September, 1999.

66. Modeling IUI Outcomes Using a Neural Network: A Large-Scale Retrospective Analysis: American Society of Reproductive Medicine and Canadian Fertility and Andrology Society Meeting, Toronto, Canada, September, 1999

 

67. Successful use of Cryopreserved Sperm Obtained by Electroejaculation for IVF/ISCI: American Society of Reproductive Medicine and Canadian Fertility and Andrology Society Meeting, Toronto, Canada, September, 1999

 

68. The Role of Diagnostic Testis Biopsy in the Modern Treatment of the Azoospermic Patient:  American Society of Reproductive Medicine and Canadian Fertility and Andrology Society Meeting, Toronto, Canada, September, 1999

 

10 Publications (not peer‑reviewed)

 

1. Niederberger C, Ross L: Epididymovasostomy: Sperm predicts success: Urology Times      18: 16, 1990

 

2. Niederberger C, Ross L: Microsurgical epididymovasostomy: Predictors of success:       Fertility Digest 3: May, 1994